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Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization.

ABSTRACT: Sequential methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients following attempted mupirocin nasal decolonization showed an increase in mupirocin resistance (MR) from 6.6% to 20%. MR isolates from patients who failed decolonization yielded indistinguishable spa types and carried multiple antimicrobial and antiseptic resistance genes, which may guide infection control and prevention.

SUBMITTER: Poovelikunnel TT 

PROVIDER: S-EPMC6125569 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization.

Poovelikunnel Toney T TT   Budri Paulo E PE   Shore Anna C AC   Coleman David C DC   Humphreys Hilary H   Fitzgerald-Hughes Deirdre D  

Antimicrobial agents and chemotherapy 20180827 9

Sequential methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) isolates from patients following attempted mupirocin nasal decolonization showed an increase in mupirocin resistance (MR) from 6.6% to 20%. MR isolates from patients who failed decolonization yielded indistinguishable <i>spa</i> types and carried multiple antimicrobial and antiseptic resistance genes, which may guide infection control and prevention. ...[more]

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