Ontology highlight
ABSTRACT:
SUBMITTER: Faletti L
PROVIDER: S-EPMC6125596 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Faletti Laura L Peintner Lukas L Neumann Simon S Sandler Sandra S Grabinger Thomas T Mac Nelly Sabine S Merfort Irmgard I Huang Chun-Hao CH Tschaharganeh Darjus D Kang Tae-Won TW Heinzmann Florian F D'Artista Luana L Maurer Ulrich U Brunner Thomas T Lowe Scott S Zender Lars L Borner Christoph C
Cell death & disease 20180905 9
Although it is well established that TNFα contributes to hepatitis, liver failure and associated hepatocarcinogenesis via the regulation of inflammation, its pro-apoptotic role in the liver has remained enigmatic. On its own, TNFα is unable to trigger apoptosis. However, when combined with the transcriptional inhibitor GaLN, it can cause hepatocyte apoptosis and liver failure in mice. Moreover, along with others, we have shown that TNFα is capable of sensitizing cells to FasL- or drug-induced ce ...[more]