Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC6125664 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Li Wenyuan W Li Qingjiao Q Kang Shuli S Same Mary M Zhou Yonggang Y Sun Carol C Liu Chun-Chi CC Matsuoka Lea L Sher Linda L Wong Wing Hung WH Alber Frank F Zhou Xianghong Jasmine XJ
Nucleic acids research 20180901 15
The detection of tumor-derived cell-free DNA in plasma is one of the most promising directions in cancer diagnosis. The major challenge in such an approach is how to identify the tiny amount of tumor DNAs out of total cell-free DNAs in blood. Here we propose an ultrasensitive cancer detection method, termed 'CancerDetector', using the DNA methylation profiles of cell-free DNAs. The key of our method is to probabilistically model the joint methylation states of multiple adjacent CpG sites on an i ...[more]