Ontology highlight
ABSTRACT:
SUBMITTER: Delville M
PROVIDER: S-EPMC6125771 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Delville Marianne M Soheili Tayebeh T Bellier Florence F Durand Amandine A Denis Adeline A Lagresle-Peyrou Chantal C Cavazzana Marina M Andre-Schmutz Isabelle I Six Emmanuelle E
Molecular therapy. Methods & clinical development 20180808
Lentiviral vectors have emerged as an efficient, safe therapeutic tool for gene therapy based on hematopoietic stem cells (HSCs) or T cells. However, the monitoring of transduced cells in preclinical models remains challenging because of the inefficient transduction of murine primary T cells with lentiviral vectors, in contrast to gammaretroviral vectors. The use of this later in preclinical proof of concept is not considered as relevant when a lentiviral vector will be used in a clinical trial. ...[more]