The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
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ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC6126087 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
Zhao Xueyun X Hua Mingqiang M Yan Shuxin S Yu Jie J Han Fengjiao F Zhong Chaoqin C Wang Ruiqing R Zhang Chen C Hou Ming M Ma Daoxin D
Journal of immunology research 20180823
The pathogenesis of multiple myeloma (MM) remains unclear and the NLRP3 inflammasome has been more and more recognized in the progression of many diseases. To investigate the role of the NLRP3 inflammasome in MM, we determined the genetic polymorphisms and expression of NLRP3 inflammasome-related genes (IL-1<i>β</i>, IL-18, CARD8, and NF-<i>κ</i>B) in MM patients, and explored their clinical relevance. Furthermore, we investigated the relationship of the NLRP3 inflammasome with Th cells in MM. O ...[more]
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