Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications.

ABSTRACT: In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardiovascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to improve immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent st

SUBMITTER: Herman PE 

PROVIDER: S-EPMC6126132 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature