Ontology highlight
ABSTRACT:
SUBMITTER: Speranza G
PROVIDER: S-EPMC6126370 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Speranza Giovanna G Anderson Larry L Chen Alice P AP Do Khanh K Eugeni Michelle M Weil Marcie M Rubinstein Larry L Majerova Eva E Collins Jerry J Horneffer Yvonne Y Juwara Lamin L Zlott Jennifer J Bishop Rachel R Conley Barbara A BA Streicher Howard H Tomaszewski Joseph J Doroshow James H JH Kummar Shivaani S
Investigational new drugs 20170812 2
Background Molecular chaperone targeting has shown promise as a therapeutic approach in human cancers of various histologies and genetic backgrounds. The purine-scaffold inhibitor PU-H71 (NSC 750424), selective for Hsp90 in epichaperome networks, has demonstrated antitumor activity in multiple preclinical cancer models. The present study was a first in-human trial of PU-H71 aimed at establishing its safety and tolerability and characterizing its pharmacokinetic (PK) profile on a weekly administr ...[more]