Contrasting Causal Effects of Workplace Interventions.

ABSTRACT: Occupational exposure guidelines are ideally based on estimated effects of static interventions that assign constant exposure over a working lifetime. Static effects are difficult to estimate when follow-up extends beyond employment because their identifiability requires additional assumptions. Effects of dynamic interventions that assign exposure while at work, allowing subjects to leave and become unexposed thereafter, are more easily identifiable but result in different estimates. Given the practical implications of exposure limits, we explored the drivers of the differences between static and dynamic interventions in a simulation study where workers could terminate employment because of an intermediate adverse health event that functions as a time-varying confounder. The two effect est

SUBMITTER: Izano MA 

PROVIDER: S-EPMC6126532 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature