Ontology highlight
ABSTRACT:
SUBMITTER: Pataki CI
PROVIDER: S-EPMC6126764 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pataki Camille I CI Rodrigues João J Zhang Lichao L Qian Junyang J Efron Bradley B Hastie Trevor T Elias Joshua E JE Levitt Michael M Kopito Ron R RR
Proceedings of the National Academy of Sciences of the United States of America 20180813 35
Despite not spanning phospholipid bilayers, monotopic integral proteins (MIPs) play critical roles in organizing biochemical reactions on membrane surfaces. Defining the structural basis by which these proteins are anchored to membranes has been hampered by the paucity of unambiguously identified MIPs and a lack of computational tools that accurately distinguish monolayer-integrating motifs from bilayer-spanning transmembrane domains (TMDs). We used quantitative proteomics and statistical modeli ...[more]