Dataset Information

Is use of the internet in midlife associated with lower dementia incidence? Results from the English Longitudinal Study of Ageing.

ABSTRACT: OBJECTIVES:Dementia is expected to affect one million individuals in the United Kingdom by 2025; its prodromal phase may start decades before its clinical onset. The aim of this study is to investigate whether use of internet from 50 years of age is associated with a lower incidence of dementia over a ten-year follow-up. METHODS:We analysed data based on 8,238 dementia free (at baseline in 2002-2004) core participants from the English Longitudinal Study of Ageing. Information on baseline use of internet was obtained through questionnaires; dementia casesness was based on participant (or informant) reported physician diagnosed dementia or overall score on the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Cox proportional hazards regression analysis was used for examining the relationship between internet use and incident dementia. RESULTS:There were 301 (5.01%) incident dementia cases during the follow-up. After full multivariable adjustment for potential confounding factors, baseline internet use was associated with a 40% reduction in dementia risk assessed between 2006-2012 (HR = 0.60 CI: 0.42-0.85; p < 0.05). CONCLUSION:This study suggests that use of internet by individuals aged 50 years or older is associated with a reduced risk of dementia. Additional studies are needed to better understand the potential causal mechanisms underlying this association.

SUBMITTER: d'Orsi E

PROVIDER: S-EPMC6127001 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Is use of the internet in midlife associated with lower dementia incidence? Results from the English Longitudinal Study of Ageing.

d'Orsi Eleonora E Xavier Andre Junqueira AJ Rafnsson Snorri Bjorn SB Steptoe Andrew A Hogervorst Eef E Orrell Martin M

Aging & mental health 20170810 11

<h4>Objectives</h4>Dementia is expected to affect one million individuals in the United Kingdom by 2025; its prodromal phase may start decades before its clinical onset. The aim of this study is to investigate whether use of internet from 50 years of age is associated with a lower incidence of dementia over a ten-year follow-up.<h4>Methods</h4>We analysed data based on 8,238 dementia free (at baseline in 2002-2004) core participants from the English Longitudinal Study of Ageing. Information on b ...[more]

PMID: 28795579

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Project description:BACKGROUND:Physical activity might reduce the risk of developing dementia. However, it is still unclear whether the protective effect differs depending on the subtype of dementia. We aimed to investigate if midlife physical activity affects the development of vascular dementia (VaD) and Alzheimer's disease (AD) differently in two large study populations with different designs. METHODS:Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n?=?197,685) exhibited reduced incidence of VaD or AD compared to matched individuals from the general population (n?=?197,684) during 21?years of follow-up (median 10, interquartile range (IQR) 5-15?years). Next, we studied the association between self-reported physical activity, stated twice 5?years apart, and incident VaD and AD in 20,639 participants in the Swedish population-based Malmo Diet and Cancer Study during 18?years of follow-up (median 15, IQR 14-17?years). Finally, we used a mouse model of AD and studied brain levels of amyloid-?, synaptic proteins, and cognitive function following 6?months of voluntary wheel running. RESULTS:Vasaloppet skiers (median age 36.0?years [IQR 29.0-46.0], 38% women) had lower incidence of all-cause dementia (adjusted hazard ratio (HR) 0.63, 95% CI 0.52-0.75) and VaD (adjusted HR 0.49, 95% CI 0.33-0.73), but not AD, compared to non-skiers. Further, faster skiers exhibited a reduced incidence of VaD (adjusted HR 0.38, 95% CI 0.16-0.95), but not AD or all-cause dementia compared to slower skiers. In the Malmo Diet and Cancer Study (median age 57.5?years [IQR 51.0-63.8], 60% women), higher physical activity was associated with reduced incidence of VaD (adjusted HR 0.65, 95% CI 0.49-0.87), but not AD nor all-cause dementia. These findings were also independent of APOE-?4 genotype. In AD mice, voluntary running did not improve memory, amyloid-?, or synaptic proteins. CONCLUSIONS:Our results indicate that physical activity in midlife is associated with lower incidence of VaD. Using three different study designs, we found no significant association between physical activity and subsequent development of AD.

Dataset Information

Is use of the internet in midlife associated with lower dementia incidence? Results from the English Longitudinal Study of Ageing.

Publications

Is use of the internet in midlife associated with lower dementia incidence? Results from the English Longitudinal Study of Ageing.

Similar Datasets

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