Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback.

ABSTRACT: Motor cortex (M1) lesions result in motor impairments, yet how M1 contributes to the control of movement remains controversial. To investigate the role of M1 in sensory guided motor coordination, we trained mice to navigate a virtual corridor using a spherical treadmill. This task required directional adjustments through spontaneous turning, while unexpected visual offset perturbations prompted induced turning. We found that M1 is essential for execution and learning of this visually guided task. Turn-selective layer 2/3 and layer 5 pyramidal tract (PT) neuron activation was shaped differentially with learning but scaled linearly with turn acceleration during spontaneous turns. During induced turns, however, layer 2/3 neurons were activated independent of behavioral response, while PT neur

SUBMITTER: Heindorf M 

PROVIDER: S-EPMC6127035 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature