Ontology highlight
ABSTRACT:
SUBMITTER: Wagner DT
PROVIDER: S-EPMC6127864 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wagner Drew T DT Zhang Zhicheng Z Meoded Roy A RA Cepeda Alexis J AJ Piel Jörn J Keatinge-Clay Adrian T AT
ACS chemical biology 20180301 4
trans-Acyltransferase assembly lines possess enzymatic domains often not observed in their better characterized cis-acyltransferase counterparts. Within this repertoire of largely unexplored biosynthetic machinery is a class of enzymes called the pyran synthases that catalyze the formation of five- and six-membered cyclic ethers from diverse polyketide chains. The 1.55 Å resolution crystal structure of a pyran synthase domain excised from the ninth module of the sorangicin assembly line highligh ...[more]