Ontology highlight
ABSTRACT:
SUBMITTER: Goins CM
PROVIDER: S-EPMC6128263 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Biochemistry 20180410 16
Tetrahydrolipstatin (THL) is a covalent inhibitor of many serine esterases. In mycobacteria, THL has been found to covalently react with 261 lipid esterases upon treatment of Mycobacterium bovis cell lysate. However, the covalent adduct is considered unstable in some cases because of the hydrolysis of the enzyme-linked THL adduct resulting in catalytic turnover. In this study, a library of THL stereoderivatives was tested against three essential Mycobacterium tuberculosis lipid esterases of inte ...[more]