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Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae).

ABSTRACT: Sex pheromones are important for agricultural pest control. The main sex pheromone components of Spodoptera litura are (Z,E)-9,11- and (Z,E)-9,12-tetradecadienyl acetate (Z9,E11-14:Ac; Z9,E12-14:Ac). In this study, we investigated the optimal conditions for encapsulation of S. litura sex pheromonesin micelles via the self-assembly method using monomethoxy poly (ethylene glycol)-poly (?-caprolactone) (MPEG-PCL) as a biodegradable wall-forming material with low toxicity. In the L9(3(4) orthogonal experiment, 3 amphiphilic block copolymers, with different hydrophilicity to hydrophobicity ratios, were examined. Optimal encapsulation conditions included stirring of MPEG5000-PCL2000 at 1000 rpm at 30°C with 2.5:1 wall-forming: core material mass ratio. S. litura sex pheromone-loaded MPEG5000-PCL2000 micelles presented a homogeneous spherical morphology with apparent core-shell structure. The release kinetics of optimized MPEG5000-PCL2000 micelles was best explained by a first-order model. Encapsulated Z9,E11-14:Ac and Z9,E12-14:Ac were released slowly, not suddenly. Methyl oleate (MO) was used as an agent to control micellar release performance. When MO content equalled block content, micelle half-life could be prolonged, thereby controlling the release speed. Overall, our results showed MPEG-PCL as a promising controlled-release substrate for sex pheromones.

SUBMITTER: Chen Y

PROVIDER: S-EPMC6128524 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae).

Chen Yixin Y Chen Xiuqin X Chen Yong Y Wei Hui H Lin Shuo S Tian Houjun H Lin Tao T Zhao Jianwei J Gu Xiaojun X

PloS one 20180907 9

Sex pheromones are important for agricultural pest control. The main sex pheromone components of Spodoptera litura are (Z,E)-9,11- and (Z,E)-9,12-tetradecadienyl acetate (Z9,E11-14:Ac; Z9,E12-14:Ac). In this study, we investigated the optimal conditions for encapsulation of S. litura sex pheromonesin micelles via the self-assembly method using monomethoxy poly (ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) as a biodegradable wall-forming material with low toxicity. In the L9(3(4) orthogonal ...[more]

PMID: 30192792

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Project description:BackgroundSpodoptera litura (Fabricius) (Lepidoptera: Noctuidae) also known as tobacco caterpillar, is one of the most serious polyphagous pests that cause economic losses to a variety of commercially important agricultural crops. Over the past few years, many conventional insecticides have been used to control this pest. However, the indiscriminate use of these chemicals has led to development of insecticide resistant populations of S. litura in addition to harmful effects on environment. Due to these ill effects, the emphasis is being laid on alternative eco-friendly control measures. Microbial control is one of the important components of integrated pest management. Thus, in search for novel biocontrol agents, the current work was carried out with the aim to evaluate the insecticidal potential of soil bacteria against S. litura.ResultsAmong the tested soil bacterial isolates (EN1, EN2, AA5, EN4 and R1), maximum mortality (74%) was exhibited by Pseudomonas sp. (EN4). The larval mortality rate increased in a dose-dependent manner. Bacterial infection also significantly delayed the larval development, reduced adult emergence, and induced morphological deformities in adults of S. litura. Adverse effects were also detected on various nutritional parameters. The infected larvae showed a significant decrease in relative growth and consumption rate as well as efficiency of conversion of ingested and digested food to biomass. Histopathological studies indicated damage to the midgut epithelial layer of larvae due to the consumption of bacteria treated diet. The infected larvae also showed a significantly decreased level of various digestive enzymes. Furthermore, exposure to Pseudomonas sp. also caused DNA damage in the hemocytes of S. litura larvae.ConclusionAdverse effects of Pseudomonas sp. EN4 on various biological parameters of S. litura indicate that this soil bacterial strain may be used as an effective biocontrol agent against insect pests.

Dataset Information

Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae).

Publications

Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae).

Similar Datasets

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