Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

ABSTRACT:

Background

Airway type 2 inflammation is usually corticosteroid sensitive, but the role of type 2 inflammation as a mechanism of asthma in patients receiving high-dose inhaled corticosteroids (ICSs) is uncertain.

Objective

We sought to determine whether airway type 2 inflammation persists in patients treated with ICSs and to evaluate the clinical features of patients with steroid-resistant airway type 2 inflammation.

Methods

We used quantitative PCR to generate a composite metric of type 2 cytokine gene expression (type 2 gene mean [T2GM]) in induced sputum cells from healthy control subjects, patients with severe asthma receiving ICSs (n = 174), and patients with nonsevere asthma receiving ICSs (n = 85). We explored relationships between asthma outcomes and T2GM valu

SUBMITTER: Peters MC 

PROVIDER: S-EPMC6128784 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature