Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.
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ABSTRACT:
SUBMITTER: Craft CS
PROVIDER: S-EPMC6128786 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.
Craft Clarissa S CS Broekelmann Thomas J TJ Mecham Robert P RP
Matrix biology : journal of the International Society for Matrix Biology 20180307
Microfibril-associated glycoproteins 1 and 2 (MAGP-1, MAGP-2) are protein components of extracellular matrix microfibrils. These proteins interact with fibrillin, the core component of microfibrils, and impart unique biological properties that influence microfibril function in vertebrates. MAGPs bind active forms of TGFβ and BMPs and are capable of modulating Notch signaling. Mutations in MAGP-1 or MAGP-2 have been linked to thoracic aneurysms and metabolic disease in humans. MAGP-2 has also bee ...[more]
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