Ontology highlight
ABSTRACT:
SUBMITTER: Morgan JE
PROVIDER: S-EPMC6128848 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Morgan Jennifer E JE Prola Alexandre A Mariot Virginie V Pini Veronica V Meng Jinhong J Hourde Christophe C Dumonceaux Julie J Conti Francesco F Relaix Frederic F Authier Francois-Jerôme FJ Tiret Laurent L Muntoni Francesco F Bencze Maximilien M
Nature communications 20180907 1
Duchenne muscular dystrophy (DMD) is a severe degenerative disorder caused by mutations in the dystrophin gene. Dystrophin-deficient muscles are characterised by progressive myofibre necrosis in which inflammation plays a deleterious role. However, the molecular mechanisms underlying inflammation-induced necrosis in muscle cells are unknown. Here we show that necroptosis is a mechanism underlying myofibre death in dystrophin-deficient muscle. RIPK1, RIPK3 and MLKL are upregulated in dystrophic m ...[more]