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Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.


ABSTRACT: Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.

SUBMITTER: Xue X 

PROVIDER: S-EPMC6128896 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.

Xue Xiangdong X   Huang Yee Y   Bo Ruonan R   Jia Bei B   Wu Hao H   Yuan Ye Y   Wang Zhongling Z   Ma Zhao Z   Jing Di D   Xu Xiaobao X   Yu Weimin W   Lin Tzu-Yin TY   Li Yuanpei Y  

Nature communications 20180907 1


Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhib  ...[more]

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