Dataset Information

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population.

ABSTRACT: Matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that can breakdown almost all extracellular matrix components. MMP8 and MMP9 have been shown to be associated with breast cancer (BC) risk in European and American populations. However, few studies have focused on the polymorphisms of MMP8 and MMP9 in Chinese Han BC patients. We investigated nine single nucleotide polymorphisms (SNPs) in 571 BC cases and 578 controls to evaluating their association with risk of BC. The frequency of the "A" allele of rs3787268 was significantly lower in BC cases than in controls (P?=?0.025). In the genetic model analysis, the minor allele "T" of rs11225394 in MMP8 was associated with increased risk of BC under the recessive model (P?=?0.019), and the minor allele "A" of rs3787268 was associated with decreased risk of BC under the dominant model (P?=?0.014). Additionally, the haplotype "AGTCA" constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype "CCG" constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P?

SUBMITTER: Wang K

PROVIDER: S-EPMC6128940 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population.

Wang Kai K Zhou Yi Y Li Gang G Wen Xinli X Kou Yuan Y Yu Jiao J He Haifeng H Zhao Qian Q Xue Feng F Wang Jin J Zhao Xinhan X

Scientific reports 20180907 1

Matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that can breakdown almost all extracellular matrix components. MMP8 and MMP9 have been shown to be associated with breast cancer (BC) risk in European and American populations. However, few studies have focused on the polymorphisms of MMP8 and MMP9 in Chinese Han BC patients. We investigated nine single nucleotide polymorphisms (SNPs) in 571 BC cases and 578 controls to evaluating their association with risk of BC. The ...[more]

PMID: 30194384

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Project description:BACKGROUND: B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal tissues, and has a potential effect to protect tumors from anti-tumor immune responses. This case-control study was carried out to determine the potential influences of B7-H4 gene polymorphisms on the susceptibility and progression of breast cancer in Han women of Northeast China. METHODS: We genotyped three B7-H4 variants (rs10754339, rs10801935 and rs3738414) and tagged all common haplotypes (frequency greater than or equal to 1%) in a Chinese population consisting of 500 breast cancer cases and 504 control individuals matched for age. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the genotypes. RESULTS: Our data indicated that, compared with the common genotype and allele of each SNP, the rs10754339 AG genotype and G allele showed a significantly increased risk of breast cancer (OR = 1.455, 95% CI 1.119-1.892; OR = 1.325, 95% CI 1.073-1.637, respectively). The rs10801935 CC genotype, the rs3738414 AA genotype and the rs3738414 A allele were associated with a significantly decreased risk of breast cancer (OR = 0.328, 95% CI 0.145-0.739; OR = 0.412, 95% CI 0.203-0.835; OR = 0.698, 95% CI 0.564-0.864, respectively). Additionally, the rs10754339 GG genotype was significantly associated with lymph node metastasis and PR status, and the G allele and the AG genotype were respectively associated with lymph node metastasis and ER status. In haplotype analysis, we observed that compared with the AAG haplotype, the AAA haplotype showed a significantly decreased risk of breast cancer (OR = 0.689, 95% CI 0.539-0.881), but the GAG haplotype was associated with a significantly increased risk of breast cancer (OR = 1.511, 95% CI 1.125-2.031). And the AAA and the GCG haplotypes also respectively have significant influences on tumor size and ER status. CONCLUSION: These results suggest that B7-H4 gene polymorphism may contribute to the sporadic breast cancer risk and prognosis in Chinese Han women.

Dataset Information

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population.

Publications

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population.

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