Ontology highlight
ABSTRACT:
SUBMITTER: Bagchi RA
PROVIDER: S-EPMC6129125 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bagchi Rushita A RA Ferguson Bradley S BS Stratton Matthew S MS Hu Tianjing T Cavasin Maria A MA Sun Lei L Lin Ying-Hsi YH Liu Dianxin D Londono Pilar P Song Kunhua K Pino Maria F MF Sparks Lauren M LM Smith Steven R SR Scherer Philipp E PE Collins Sheila S Seto Edward E McKinsey Timothy A TA
JCI insight 20180809 15
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhibit enhanced thermogenic potential and, in response to high-fat feeding, attenuated obesity, improved insulin sensitivity, and reduced hepatic steatosis. Ex vivo and cell-based assays revealed that HDA ...[more]