Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Riba A
PROVIDER: S-EPMC6129472 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Biophysical journal 20180601 11
Consensus-designed tetratricopeptide repeat proteins are highly stable, modular proteins that are strikingly amenable to rational engineering. They therefore have tremendous potential as building blocks for biomaterials and biomedicine. Here, we explore the possibility of extending the loops between repeats to enable further diversification, and we investigate how this modification affects stability and folding cooperativity. We find that extending a single loop by up to 25 residues does not dis ...[more]