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Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

ABSTRACT: BACKGROUND/OBJECTIVES:Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month open label extension study following an 18 months randomized placebo-controlled trial (RCT) on the efficacy, safety, and tolerability of metformin in adolescents with obesity and insulin resistance was performed. SUBJECTS/METHODS:After completion of the RCT, metformin was offered to all participants with a body mass index standard deviation score (BMI-sds)?>?2.3 and Homeostasis Model Assessment for Insulin Resistance (HOMA-IR)???3.4. Endpoints were change in BMI and HOMA-IR. RESULTS:Overall, 31/42 participants completed the extension study (74% girls, median age 14.8 (11.6 - 17.9), BMI 31.2 (22.3 - 45.1), HOMA-IR 3.4 (0.2 - 8.8)). At start, 22/42 (52.4%) participants were eligible for metformin of which 13 (59.0%) agreed with treatment. In participants who continued metformin, an increase was observed in BMI (+2.2 (+0.2 to +9.0)) and HOMA-IR (+13.7 (+1.6 to +48.3)). In metformin naive participants, BMI stabilized after an initial decrease (+0.5 (-2.1 to +5.1)). For HOMA-IR, a decrease was observed (-1.1 (-4.6 to +1.4)). CONCLUSION:While metformin treatment in metformin naive participants seems to result in an initial decrease in BMI and HOMA-IR, there is no evidence for sustained effect after prolonged use in adolescents. Limited compliance and/or insufficient dose may explain the differences in long-term effects between adolescents and adults.

SUBMITTER: Lentferink YE

PROVIDER: S-EPMC6129504 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

Lentferink Y E YE van der Aa M P MP van Mill E G A H EGAH Knibbe C A J CAJ van der Vorst M M J MMJ

Nutrition & diabetes 20180910 1

<h4>Background/objectives</h4>Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month open label extension study following an 18 months randomized placebo-controlled trial (RCT) on the efficacy, safety, and tolerability of metformin in adolescents with obesity and insulin resistance was performed.<h4>Subjects/methods</h4>After completion of the RCT ...[more]

PMID: 30197416

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Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

Publications

Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

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