Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

ABSTRACT:

Background/objectives

Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month open label extension study following an 18 months randomized placebo-controlled trial (RCT) on the efficacy, safety, and tolerability of metformin in adolescents with obesity and insulin resistance was performed.

Subjects/methods

After completion of the RCT, metformin was offered to all participants with a body mass index standard deviation score (BMI-sds) > 2.3 and Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) ≥ 3.4. Endpoints were change in BMI and HOMA-IR.

Results

Overall, 31/42 participants completed the extension study (74%

SUBMITTER: Lentferink YE 

PROVIDER: S-EPMC6129504 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature