Ontology highlight
ABSTRACT:
SUBMITTER: Li JA
PROVIDER: S-EPMC6129552 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Li Jun-An JA Liu Bai-Chun BC Song Ying Y Chen Xin X
American journal of translational research 20180815 8
Colon cancer is one of the most fatal cancers in the United States, and is characterized by the presence of chromosomal instability (CIN), causes of which are largely unclear. Emerging evidence indicates that abnormal spindle geometry and supernumerary centrosomes lead to CIN in cells. However, if and how spindle geometry defects and centrosomes amplification occur in colon cancer remains unknown. Here we show that decrease in the cell cycle regulatory protein, cyclin A2, induces spindle geometr ...[more]