Ontology highlight
ABSTRACT:
SUBMITTER: Schaerli Y
PROVIDER: S-EPMC6129954 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Schaerli Yolanda Y Jiménez Alba A Duarte José M JM Mihajlovic Ljiljana L Renggli Julien J Isalan Mark M Sharpe James J Wagner Andreas A
Molecular systems biology 20180910 9
Phenotypic variation is the raw material of adaptive Darwinian evolution. The phenotypic variation found in organismal development is biased towards certain phenotypes, but the molecular mechanisms behind such biases are still poorly understood. Gene regulatory networks have been proposed as one cause of constrained phenotypic variation. However, most pertinent evidence is theoretical rather than experimental. Here, we study evolutionary biases in two synthetic gene regulatory circuits expressed ...[more]