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ABSTRACT: Background
Currently, there is no consensus on the efficacy and safety of lamivudine (LAM) plus tenofovir disoproxil fumarate (TDF) combination therapy versus lamivudine monotherapy in HBV/HIV coinfected patients.Methods
A comprehensive literature search was performed in English and Chinese databases. Both relevant dichotomous and continuous variables were extracted, and the combined outcomes were expressed as a risk ratio (RR) or a standard mean difference (SMD).Results
Eleven eligible studies were included in our analysis. For HBV-relevant outcomes, the proportion of patients with undetectable HBV, the rates of serum alanine aminotransferase (ALT) normalization and hepatitis B e antigen (HBeAg) loss were higher in the combination therapy group than the monotherapy group (RR?=?1.42, 95% CI: 1.14-1.76, P?=?0.002; RR?=?1.36, 95% CI: 1.17-1.58, P?ConclusionLAM plus TDF combination therapy was more efficacious than LAM monotherapy in HBV/HIV coinfected patients. As time passes, this difference becomes more pronounced.
SUBMITTER: Luo A
PROVIDER: S-EPMC6130076 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Luo Aoran A Jiang Xiaoyan X Ren Hong H
Virology journal 20180910 1
<h4>Background</h4>Currently, there is no consensus on the efficacy and safety of lamivudine (LAM) plus tenofovir disoproxil fumarate (TDF) combination therapy versus lamivudine monotherapy in HBV/HIV coinfected patients.<h4>Methods</h4>A comprehensive literature search was performed in English and Chinese databases. Both relevant dichotomous and continuous variables were extracted, and the combined outcomes were expressed as a risk ratio (RR) or a standard mean difference (SMD).<h4>Results</h4> ...[more]