Ontology highlight
ABSTRACT:
SUBMITTER: Byrne M
PROVIDER: S-EPMC6130097 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Byrne Michael M Savani Bipin B Savona Michael R MR
Therapeutic advances in hematology 20180716 9
Primary myelofibrosis (PMF) is a disease characterized by bone marrow fibrosis, extramedullary hematopoiesis, risk of transformation to acute myeloid leukemia, and a substantial symptom burden with diminished quality of life. Allogeneic hematopoietic cell transplantation (HCT) is the only curative option; however, disease relapse and graft <i>versus</i> host disease (GVHD) are significant barriers to long-term survival. The discovery of the <i>JAK2 V617F</i> mutation, and subsequent development ...[more]