Ontology highlight
ABSTRACT:
SUBMITTER: Henderson AR
PROVIDER: S-EPMC6130367 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Henderson Andrew R AR Henley Madeleine J MJ Foster Nicholas J NJ Peiffer Amanda L AL Beyersdorf Matthew S MS Stanford Kevon D KD Sturlis Steven M SM Linhares Brian M BM Hill Zachary B ZB Wells James A JA Cierpicki Tomasz T Brooks Charles L CL Fierke Carol A CA Mapp Anna K AK
Proceedings of the National Academy of Sciences of the United States of America 20180820 36
Transcriptional coactivators are a molecular recognition marvel because a single domain within these proteins, the activator binding domain or ABD, interacts with multiple compositionally diverse transcriptional activators. Also remarkable is the structural diversity among ABDs, which range from conformationally dynamic helical motifs to those with a stable core such as a β-barrel. A significant objective is to define conserved properties of ABDs that allow them to interact with disparate activa ...[more]