Ontology highlight
ABSTRACT:
SUBMITTER: Early JO
PROVIDER: S-EPMC6130388 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Early James O JO Menon Deepthi D Wyse Cathy A CA Cervantes-Silva Mariana P MP Zaslona Zbigniew Z Carroll Richard G RG Palsson-McDermott Eva M EM Angiari Stefano S Ryan Dylan G DG Corcoran Sarah E SE Timmons George G Geiger Sarah S SS Fitzpatrick Darren J DJ O'Connell Daniel D Xavier Ramnik J RJ Hokamp Karsten K O'Neill Luke A J LAJ Curtis Annie M AM
Proceedings of the National Academy of Sciences of the United States of America 20180820 36
A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal tha ...[more]