Ontology highlight
ABSTRACT:
SUBMITTER: Gallagher DT
PROVIDER: S-EPMC6130425 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Gallagher D Travis DT Galvin Connor V CV Karageorgos Ioannis I
Acta crystallographica. Section F, Structural biology communications 20180829 Pt 9
As the link between antigen binding and immune activation, the antibody Fc region has received extensive structural study. In this report, the structure of the Fc fragment of the NIST IgG1 mAb (reference material 8671) is described at 2.1 Å resolution in space group P2<sub>1</sub>2<sub>1</sub>2<sub>1</sub>, with approximate unit-cell parameters a = 50, b = 80, c = 138 Å. Prior Fc structures with a wide variety of modifications are also surveyed, focusing on those in the same crystal form. To fac ...[more]