Andrographolide relieved pathological pain generated by spared nerve injury model in mice.

ABSTRACT:

Context

Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia.

Objective

The objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model.

Material and methods

Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group). Andro or NSAIDS (diclofenac salt) were injected intraperitoneally at 5 mg/kg body weight daily. Mechanical allodynia was assessed by von Frey tests at 3, 7

SUBMITTER: Wang HC 

PROVIDER: S-EPMC6130553 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature