The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats.

ABSTRACT: CONTEXTHepatocellular carcinoma (HCC) is among the most well-known threatening tumours around the world, and the outlook remains bleak. Moringa oleifera Lam. (Moringaceae) exhibits antitumor, antioxidant and hepatoprotective properties.OBJECTIVESTo assess the chemo-prophylactic proficiency and other likely activities of Moringa oleifera leaf ethanol extract (MOLEE) against diethyl nitrosamine (DEN)-induced HCC.MATERIALS AND METHODSWistar rats were gastrogavaged with MOLEE (500?mg/kg) for one week and then gastrogavaged with MOLEE and DEN (10?mg/kg) for the following 16?weeks. The progressions of the histological components, serum biomarkers and oxidation of DNA of the liver tissues were resolved to assess the prophylactic impacts. The lipid oxidative biomarker, the cancer prevention agent status and apoptotic proteins were surveyed to assess the potential mechanisms.RESULTSThe MOLEE LD50 was estimated to be 5585?mg/kg. MOLEE (500?mg/kg) administration fundamentally repressed the expansion event of knobs and the normal knob number per knob-bearing livers prompted by DEN, enhanced hepatocellular appearance and altogether significantly decreased (p?DISCUSSION AND CONCLUSIONSThe outcomes presume that MOLEE inspired critical defensive impacts against DEN-induced hepatocarcinogenesis that might be identified with the implementation of antioxidant activity and actuation of apoptosis.

SUBMITTER: Sadek KM 

PROVIDER: S-EPMC6130573 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature