Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats.

ABSTRACT:

Context

Cyclocarya paliurus (Batal) Iljinskaja (Juglandaceae) is an edible and medicinal plant; the leaves are used in Chinese folkloric medicine to treat dyslipidaemia and diabetes.

Objective

This study evaluates the antihyperlipidaemic potential of the triterpenic acid-enriched fraction (TAE) from C. paliurus and the underlying mechanism.

Materials and methods

The hyperlipidaemic rats were induced by high fat diet for 6 weeks. After oral administration of TAE (200 and 400?mg/kg), the neutral fraction (150 and 300?mg/kg) and statin (4?mg/kg) to the hyperlipidaemic rats for 4 weeks, lipid profile and apolipoprotein (apoB48) level in plasma, and the expression levels of apoB48, microsomal triglyceride transfer protein (MTP), phosphorylation of mitogen-activated protein kinase (MAPK) and tumour necrosis factor ? (TNF-?) in intestine were examined. The main constituents in the TAE were identified by HPLC-MS.

Results

TAE administration (400?mg/kg) decreased the levels of atherogenic lipids in serum and liver (p?Conclusion and discussionThese findings suggested that TAE possessed antihyperlipidaemic activity partially involved in the inhibitory effect on apoB48 overproduction, which may provide evidence about its potential role in ameliorating dyslipidaemia.

SUBMITTER: Wu Z 

PROVIDER: S-EPMC6130609 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature