Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire.
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ABSTRACT:
SUBMITTER: Bommarito PA
PROVIDER: S-EPMC6130838 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire.
Bommarito Paige A PA Martin Elizabeth E Smeester Lisa L Palys Thomas T Baker Emily R ER Karagas Margaret R MR Fry Rebecca C RC
Reproductive toxicology (Elmsford, N.Y.) 20170806
Exposure to inorganic arsenic (iAs) during pregnancy is associated with adverse health outcomes present both at birth and later in life. A biological mechanism may include epigenetic and genomic alterations in fetal genes involved in immune functioning. To investigate the role of the maternal immune response to in utero iAs exposure, we conducted an analysis of the expression of immune-related genes in pregnant women from the New Hampshire Birth Cohort Study. A set of 31 genes was identified wit ...[more]
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