Walking a fine line between ?-cell secretion and proliferation.
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ABSTRACT:
SUBMITTER: Vella A
PROVIDER: S-EPMC6130962 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Walking a fine line between β-cell secretion and proliferation.
Vella Adrian A Matveyenko Aleksey A
The Journal of biological chemistry 20180901 36
Of the many common genetic variants associated with type 2 diabetes, that in <i>TCF7L2</i> remains the most studied because it has the greatest effect size. However, the mechanism by which this variant alters diabetes risk remains elusive. A new study adds another layer of complexity, suggesting that the effects of TCF7L2 are context-dependent, and highlights a novel interaction that might bias a β-cell to a secretory or proliferative phenotype. This in turn might open up new avenues to the rest ...[more]
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