Ontology highlight
ABSTRACT:
SUBMITTER: Inman GJ
PROVIDER: S-EPMC6131170 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Inman Gareth J GJ Wang Jun J Nagano Ai A Alexandrov Ludmil B LB Purdie Karin J KJ Taylor Richard G RG Sherwood Victoria V Thomson Jason J Hogan Sarah S Spender Lindsay C LC South Andrew P AP Stratton Michael M Chelala Claude C Harwood Catherine A CA Proby Charlotte M CM Leigh Irene M IM
Nature communications 20180910 1
Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly differentiated tumours, with accompanying clinical data from a longitudinal study of immunosuppressed and immunocompetent patients and integrate this analysis with independent gene expression studies. We identify commonly mutated genes, copy number changes a ...[more]