Ontology highlight
ABSTRACT:
SUBMITTER: Castilho A
PROVIDER: S-EPMC6131413 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Castilho Alexandra A Beihammer Gernot G Pfeiffer Christina C Göritzer Kathrin K Montero-Morales Laura L Vavra Ulrike U Maresch Daniel D Grünwald-Gruber Clemens C Altmann Friedrich F Steinkellner Herta H Strasser Richard R
Plant biotechnology journal 20180325 10
N-glycosylation is critical for recombinant glycoprotein production as it influences the heterogeneity of products and affects their biological function. In most eukaryotes, the oligosaccharyltransferase is the central-protein complex facilitating the N-glycosylation of proteins in the lumen of the endoplasmic reticulum (ER). Not all potential N-glycosylation sites are recognized in vivo and the site occupancy can vary in different expression systems, resulting in underglycosylation of recombina ...[more]