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Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma.


ABSTRACT: Williams-Beuren syndrome (WBS) is a multisystemic neurodevelopmental disorder caused by a hemizygous deletion on chromosome 7q11.23. Though at present there is a limited number of reports on WBS patients with tumors, most cases are related to blood cancer in children with WBS. We describe a case of Burkitt lymphoma in a 21-year-old man with WBS. In addition to providing a summary of published reports describing tumors observed in patients with WBS, we present a hypothesis about a possible mechanism of oncogenesis. In particular, we identified some significantly dysregulated cancer-related genes using blood samples from this patient at the age of 19 years (who have not yet developed Burkitt lymphoma). Our findings may provide a new perspective on the relation between WBS and Burkitt lymphoma.

SUBMITTER: Kimura R 

PROVIDER: S-EPMC6131482 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma.

Kimura Ryo R   Ishii Yuko Y   Tomiwa Kiyotaka K   Awaya Tomonari T   Nakata Masatoshi M   Kato Takeo T   Okazaki Shin S   Heike Toshio T   Hagiwara Masatoshi M  

Frontiers in genetics 20180904


Williams-Beuren syndrome (WBS) is a multisystemic neurodevelopmental disorder caused by a hemizygous deletion on chromosome 7q11.23. Though at present there is a limited number of reports on WBS patients with tumors, most cases are related to blood cancer in children with WBS. We describe a case of Burkitt lymphoma in a 21-year-old man with WBS. In addition to providing a summary of published reports describing tumors observed in patients with WBS, we present a hypothesis about a possible mechan  ...[more]

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