Ontology highlight
ABSTRACT:
SUBMITTER: Lang E
PROVIDER: S-EPMC6131553 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Lång Emma E Połeć Anna A Lång Anna A Valk Marijke M Blicher Pernille P Rowe Alexander D AD Tønseth Kim A KA Jackson Catherine J CJ Utheim Tor P TP Janssen Liesbeth M C LMC Eriksson Jens J Bøe Stig Ove SO
Nature communications 20180910 1
Epithelial sheet spreading is a fundamental cellular process that must be coordinated with cell division and differentiation to restore tissue integrity. Here we use consecutive serum deprivation and re-stimulation to reconstruct biphasic collective migration and proliferation in cultured sheets of human keratinocytes. In this system, a burst of long-range coordinated locomotion is rapidly generated throughout the cell sheet in the absence of wound edges. Migrating cohorts reach correlation leng ...[more]