The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase gene with Obesity and Insulin Resistance.
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ABSTRACT: Objectives
Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).Methods
We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.Results
A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR.Conclusions
We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.
SUBMITTER: Prakash J
PROVIDER: S-EPMC6131921 | biostudies-literature |
REPOSITORIES: biostudies-literature
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2009-03-08 | GSE11991 | GEO
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