Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6132070 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Liu Xuena X Li Nan N Zhang Hua H Liu Jing J Zhou Nan N Ran Chunxiao C Chen Xiaoyan X Lu Yongbo Y Wang Xiaofang X Qin Chunlin C Xiao Jing J Liu Chao C
European journal of oral sciences 20180814 5
The glycosaminoglycan (GAG) chains attached to the core proteins of proteoglycans exert multiple roles, such as enriching signal molecules and regulating the binding of ligands to the corresponding receptors. A newly identified kinase - family with sequence similarity 20 member B (FAM20B) - is essential for the formation of GAG chains. The FAM20B protein phosphorylates the initial xylose on the side chain of a serine residue in the protein. Although the GAG chains of proteoglycans are believed t ...[more]