Ontology highlight
ABSTRACT:
SUBMITTER: Cosson V
PROVIDER: S-EPMC6132363 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cosson Valérie V Schaedeli-Stark Franziska F Arab-Alameddine Mona M Chavanne Clarisse C Guerini Elena E Derks Michael M Mallalieu Navita L NL
Clinical and translational science 20180627 5
Dizziness, the most frequently observed adverse event in patients with major depressive disorder, was observed with basimglurant, a selective, orally active metabotropic glutamate receptor subtype 5 negative allosteric modulator. The potential relationship between dizziness and basimglurant exposure was explored. The pharmacokinetics of basimglurant was characterized with nonlinear mixed effects modeling using data from 288 trial participants enrolled in five clinical trials. The pharmacokinetic ...[more]