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Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning.

ABSTRACT: PURPOSE:Working in conditions with daily exposure to organic solvents for many years can result in a disease known as chronic solvent-induced encephalopathy (CSE). The aims for this study were to describe the neuropsychological course of CSE after first diagnosis and to detect prognostic factors for neuropsychological impairment after diagnosis. METHODS:This prospective study follows a Dutch cohort of CSE patients who were first diagnosed between 2001 and 2011 and underwent a second neuropsychological assessment 1.5-2 years later. Cognitive subdomains were assessed and an overall cognitive impairment score was calculated. Paired t tests and multivariate linear regression analyses were performed to describe the neuropsychological course and to obtain prognostic factors for the neuropsychological functioning at follow-up. RESULTS:There was a significant improvement on neuropsychological subdomains at follow-up, with effect sizes between small and medium (Cohen's d 0.27-0.54) and a significant overall improvement of neuropsychological impairment with a medium effect size (Cohen's d 0.56). Prognostic variables for more neuropsychological impairment at follow-up were a higher level of neuropsychological impairment at diagnosis and having a comorbid diagnosis of a psychiatric disorder at diagnosis. CONCLUSIONS:Results are in line with previous research on the course of CSE, stating that CSE is a non-progressive disease after cessation of exposure. However, during follow-up the percentage patients with permanent work disability pension increased from 14 to 37%. Preventive action is needed in countries where exposure to organic solvents is still high to prevent new cases of CSE.

SUBMITTER: van Valen E

PROVIDER: S-EPMC6132664 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning.

van Valen Evelien E Wekking Ellie E van Hout Moniek M van der Laan Gert G Hageman Gerard G van Dijk Frank F de Boer Angela A Sprangers Mirjam M

International archives of occupational and environmental health 20180625 7

<h4>Purpose</h4>Working in conditions with daily exposure to organic solvents for many years can result in a disease known as chronic solvent-induced encephalopathy (CSE). The aims for this study were to describe the neuropsychological course of CSE after first diagnosis and to detect prognostic factors for neuropsychological impairment after diagnosis.<h4>Methods</h4>This prospective study follows a Dutch cohort of CSE patients who were first diagnosed between 2001 and 2011 and underwent a seco ...[more]

PMID: 29943196

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Dataset Information

Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning.

Publications

Chronic solvent-induced encephalopathy: course and prognostic factors of neuropsychological functioning.

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