Ontology highlight
ABSTRACT:
SUBMITTER: Rawal Y
PROVIDER: S-EPMC6133248 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20180405 2
Gcn4 is a yeast transcriptional activator induced by amino acid starvation. ChIP-seq analysis revealed 546 genomic sites occupied by Gcn4 in starved cells, representing ∼30% of Gcn4-binding motifs. Surprisingly, only ∼40% of the bound sites are in promoters, of which only ∼60% activate transcription, indicating extensive negative control over Gcn4 function. Most of the remaining ∼300 Gcn4-bound sites are within coding sequences (CDSs), with ∼75 representing the only bound sites near Gcn4-induced ...[more]