Dataset Information

MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis.

ABSTRACT:

Background

MicroRNAs (miRs) play a vital role in the occurrence, development, and progression of human cancers, but its role in the prognosis of ovarian cancer is unclear.

Methods

We performed a meta-analysis by searching PubMed, Embase, and Web of Science databases for eligible studies. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to explore the association between miRs expression and overall survival (OS) and progression-free survival (PFS) on ovarian cancer patients. We also used Kaplan-Meier to analyze the relationship between miRs and OS in OncoLnc dataset.

Results

A total of 15 records were included into the meta-analysis. The expression level of miR-200 family showed significant association with OS (HR?=?0.78, 95% CI: 0.64-0.94) and insignificant association with PFS (HR?=?0.72, 95% CI: 0.50-1.03). Subgroup analysis revealed that an increased expression level of miR-200c was associated with better OS (HR?=?0.59, 95% CI: 0.45-0.74). An increased expression level of miR-200a, miR-200c, and miR-141 was associated with better PFS (miR-200a, HR?=?0.59, 95% CI: 0.42-0.75; miR-200c, HR?=?0.50, 95% CI: 0.14-0.87, miR-141, HR?=?0.38, 95% CI: 0.12-0.63). Similarly, higher expression of miR-30 family was associated with elevated OS/PFS for ovarian cancer (OS, HR?=?0.43, 95% CI: 0.13-0.74; PFS, HR?=?0.76, 95% CI: 0.64-0.87). The OncoLnc dataset presented that elevated expression level of miR-30d-5p was associated with better OS (n?=?470, P?=?.0197).

Conclusion

The meta-analysis reveals that miR-200 family and miR-30 family could be promising prognostic biomarkers of ovarian cancer.

SUBMITTER: Shi M

PROVIDER: S-EPMC6133642 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis.

Shi Min M Mu Yulan Y Zhang Hui H Liu Ming M Wan Jipeng J Qin Xiaoyan X Li Changzhong C

Medicine 20180801 32

<h4>Background</h4>MicroRNAs (miRs) play a vital role in the occurrence, development, and progression of human cancers, but its role in the prognosis of ovarian cancer is unclear.<h4>Methods</h4>We performed a meta-analysis by searching PubMed, Embase, and Web of Science databases for eligible studies. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to explore the association between miRs expression and overall survival (OS) and progression-free survival (PFS) on ovar ...[more]

PMID: 30095616

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Dataset Information

MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis.

Background

Methods

Results

Conclusion

Publications

MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis.

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