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Midregional pro-atrial natriuretic peptide is a superior biomarker to N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failure patients with preserved ejection fraction.


ABSTRACT:

Objectives

To explore that if mid-regional sequence of pro-A-type natriuretic peptide (MR-proANP) may have a good value of diagnosis in heart failure with preserved ejection fraction (HFpEF) compared with N-terminal pro-B-type natriuretic peptide (NT-proBNP).

Methods

Participants with cardiovascular disease who were enrolled in this study were divided into the nonheart failure (non-HF) group (n?=?75), HFpEF group (n?=?65), and HF with reduced ejection fraction (HFrEF) group (n?=?50). The MR-proANP and NT-proBNP levels in plasma from all patients were measured by enzyme-linked immunosorbent assay.

Results

The plasma levels of MR-proANP and NT-proBNP in HFpEF and HFrEF groups were higher than those in non-HF group (P?ConclusionResults indicated that MR-proANP may be more sensitive and specific than NT-proBNP in diagnosing HFpEF. It may be used as a potential diagnostic biomarker in patients with HFpEF.

SUBMITTER: Cui K 

PROVIDER: S-EPMC6133645 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Midregional pro-atrial natriuretic peptide is a superior biomarker to N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failure patients with preserved ejection fraction.

Cui Kun K   Huang Wei W   Fan Jinqi J   Lei Han H  

Medicine 20180901 36


<h4>Objectives</h4>To explore that if mid-regional sequence of pro-A-type natriuretic peptide (MR-proANP) may have a good value of diagnosis in heart failure with preserved ejection fraction (HFpEF) compared with N-terminal pro-B-type natriuretic peptide (NT-proBNP).<h4>Methods</h4>Participants with cardiovascular disease who were enrolled in this study were divided into the nonheart failure (non-HF) group (n = 75), HFpEF group (n = 65), and HF with reduced ejection fraction (HFrEF) group (n = 5  ...[more]

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