Ontology highlight
ABSTRACT:
SUBMITTER: Tanimura N
PROVIDER: S-EPMC6133724 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Tanimura Nobuyuki N Liao Ruiqi R Wilson Gary M GM Dent Matthew R MR Cao Miao M Burstyn Judith N JN Hematti Peiman P Liu Xin X Zhang Yuannyu Y Zheng Ye Y Keles Sunduz S Xu Jian J Coon Joshua J JJ Bresnick Emery H EH
Developmental cell 20180816 5
By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity of GATA-1, a key determinant of erythrocyte differentiation. To discover biological consequences of the metal cofactor-transcription factor mechanism, we merged GATA-1/heme-regulated sectors of the proteome and transcriptome. This multi-omic analysis revealed a GATA-1/heme circuit involving hemoglobin subunits, ubiquitin ...[more]