Ontology highlight
ABSTRACT: Study objectives
Insomnia frequently co-occurs with fibromyalgia, which is associated with gray matter atrophy. We examined the effect of cognitive behavioral therapy for insomnia (CBT-I) and pain (CBT-P) on cortical thickness.Methods
Patients with fibromyalgia and insomnia underwent MRI before and after random assignment to CBT-I (n = 14), CBT-P (n = 16), or waitlist control (WLC; n = 7).Results
Repeated-measures analyses of variance revealed significant interactions for two regions (left lateral orbitofrontal cortex, left rostral middle frontal, Ps < .05) and trends for four regions (right medial orbitofrontal cortex, right posterior cingulate, left caudal middle frontal, left transverse temporal; Ps < .10). Cortical thickness increased in all regions for CBT-I and decreased in five regions for CBT-P and WLC. Hierarchical regressions revealed that for the CBT-I group, reductions in wake after sleep onset were associated with an increase in cortical thickness.Conclusions
Our pilot study presents novel evidence suggesting that CBT-I may slow or reverse cortical gray matter atrophy in patients with fibromyalgia and insomnia.Clinical trial registration
Registry: ClinicalTrials.gov, Identifier: NCT02001077, Title: Sleep and Pain Interventions in Fibromyalgia (SPIN), URL: https://clinicaltrials.gov/ct2/show/NCT02001077.
SUBMITTER: McCrae CS
PROVIDER: S-EPMC6134244 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
McCrae Christina S CS Mundt Jennifer M JM Curtis Ashley F AF Craggs Jason G JG O'Shea Andrew M AM Staud Roland R Berry Richard B RB Perlstein William M WM Robinson Michael E ME
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20180915 9
<h4>Study objectives</h4>Insomnia frequently co-occurs with fibromyalgia, which is associated with gray matter atrophy. We examined the effect of cognitive behavioral therapy for insomnia (CBT-I) and pain (CBT-P) on cortical thickness.<h4>Methods</h4>Patients with fibromyalgia and insomnia underwent MRI before and after random assignment to CBT-I (n = 14), CBT-P (n = 16), or waitlist control (WLC; n = 7).<h4>Results</h4>Repeated-measures analyses of variance revealed significant interactions for ...[more]