Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Broadbent H
PROVIDER: S-EPMC6135234 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Rodriguez-Broadbent Henry H Law Philip J PJ Sud Amit A Palin Kimmo K Tuupanen Sari S Gylfe Alexandra A Hänninen Ulrika A UA Cajuso Tatiana T Tanskanen Tomas T Kondelin Johanna J Kaasinen Eevi E Sarin Antti-Pekka AP Ripatti Samuli S Eriksson Johan G JG Rissanen Harri H Knekt Paul P Pukkala Eero E Jousilahti Pekka P Salomaa Veikko V Palotie Aarno A Renkonen-Sinisalo Laura L Lepistö Anna A Böhm Jan J Mecklin Jukka-Pekka JP Al-Tassan Nada A NA Palles Claire C Martin Lynn L Barclay Ella E Farrington Susan M SM Timofeeva Maria N MN Meyer Brian F BF Wakil Salma M SM Campbell Harry H Smith Christopher G CG Idziaszczyk Shelley S Maughan Timothy S TS Kaplan Richard R Kerr Rachel R Kerr David D Passarelli Michael N MN Figueiredo Jane C JC Buchanan Daniel D DD Win Aung K AK Hopper John L JL Jenkins Mark A MA Lindor Noralane M NM Newcomb Polly A PA Gallinger Steven S Conti David D Schumacher Fred F Casey Graham G Aaltonen Lauri A LA Cheadle Jeremy P JP Tomlinson Ian P IP Dunlop Malcolm G MG Houlston Richard S RS
International journal of cancer 20170406 12
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variables ...[more]