Ontology highlight
ABSTRACT:
SUBMITTER: Roldan R
PROVIDER: S-EPMC6135579 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
ACS catalysis 20180808 9
Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone reaction for the synthesis of unusual sugars and chiral building blocks. We investigated d-fructose-6-phosphate aldolase from <i>E. coli</i> (FSA) D6X variants as catalysts for the aldol additions of ethanal and nonfunctionalized linear and cyclic aliphatic ketones as nucleophiles to nonphosphorylated hydroxyaldehydes. Thus, addition of propanone, cyclobutanone, cyclopentanone, or ethanal to 3-hydroxyprop ...[more]