The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
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ABSTRACT:
SUBMITTER: Gyllborg D
PROVIDER: S-EPMC6135723 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
Gyllborg Daniel D Ahmed Maqsood M Toledo Enrique M EM Theofilopoulos Spyridon S Yang Shanzheng S Ffrench-Constant Charles C Arenas Ernest E
Stem cell reports 20180823 3
The development of midbrain dopaminergic (mDA) neurons is controlled by multiple morphogens and transcription factors. However, little is known about the role of extracellular matrix proteins in this process. Here we examined the function of roof plate-specific spondins (RSPO1-4) and the floor plate-specific, spondin 1 (SPON1). Only RSPO2 and SPON1 were expressed at high levels during mDA neurogenesis, and the receptor LGR5 was expressed by midbrain floor plate progenitors. Surprisingly, RSPO2, ...[more]
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